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Showing posts with label Developments. Show all posts
Showing posts with label Developments. Show all posts

Tic Disorder Therapeutics - Pipeline Analysis 2020, Clinical Trials & Results, Patents, Designations, Collaborations


Tic disorder is a type of mental disorder, characterized by sudden and nonrhythmic movements. According to the World Health Organisation (WHO), this disease can be categorized into five types; transient, combined vocal and multiple motor, unspecified, and chronic motor tic disorder.
Some of the symptoms of the disease are facial grimacing, excessive blinking, uncontrollable movements of the legs, and sound such as throat clearing. Majorly found in children, this disease can be treated by a combination therapy of drugs, that reduce the dopamine concentration in the brain.

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However, cognitive behavioural therapy is also being used for the treatment of this disease. Abide Therapeutics Inc. is in the process of developing ABX-1431 for the treatment of tic disorder. Neurocrine Biosciences is in the process of developing valbenazine as a vesicular monoamine transporter 2 inhibitor for the treatment of this disorder.

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The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.

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Spasticity Therapeutics - Pipeline Analysis , Clinical Trials & Results, Patents, Designations, Collaborations


Spasticity is a condition in which certain muscles are continuously contracted. The constant muscle contraction causes stiffness or tightness of the muscles and can interfere with normal movement, speech and gait in a patient.

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Spasticity is usually caused by damage to the portion of the brain or spinal cord that controls voluntary movement. This damage causes a change in the balance of signals between the nervous system and muscles, leading to increased activity in muscles.

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Spasticity negatively affects muscles and joints of the extremities and is particularly harmful to growing children. Currently available treatment options for this disease include oral medications and interventional procedures. Certain conditions that may cause spasticity are traumatic brain injury, spinal cord injury, brain damage due to a lack of oxygen, stroke, encephalitis, and meningitis.

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The drug candidates of for treating this condition include, but are not limited to, Arbaclofen extended release and Botulinum toxin E. Some of the companies having drugs in spasticity pipeline are Osmotica Pharmaceutical, Ipsen Pharma, and Canbex Therapeutics Ltd.

The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.

Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.

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Polymyalgia Rheumatica Therapeutics - Pipeline Analysis, Clinical Trials & Results


Polymyalgia rheumatica is an inflammatory disorder which causes stiffness and aching, and usually affects adults over the age of 50 years. This disease affects women somewhat more than men. The cause of polymyalgia rheumatica is unknown.

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Polymyalgia rheumatica is related to another inflammatory disorder, giant cell arteritis, which can cause vision difficulties, scalp tenderness, jaw pain, and headaches. Pain in shoulders, neck, upper arms, buttocks, hips and thighs; stiffness in the affected areas; limited range of motion in affected areas; and stiffness in wrists, elbows and knees are some of the common symptoms of polymyalgia rheumatica.

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Involvement of the upper arms, with trouble raising them above the shoulders is common in the patients with this disease. Corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) are common medications for the treatment of polymyalgia rheumatica. GlaxoSmithKline plc is in the process of developing sirukumab as an interleukin 6 (IL6) human monoclonal antibody for the treatment of polymyalgia rheumatica. Other than this Chugai Pharmaceutical Co. Ltd., and Eli Lilly and Company are also involved in polymyalgia rheumatica pipeline.

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The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.

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Adrenoleukodystrophy (ALD) Therapeutics Pipeline Analysis by Therapeutics, Diagnostics, Patient, Drugs Policy and Regulatory Landscape


Adrenoleukodystrophy (ALD) Therapeutics Pipeline Analysis 2019, Clinical Trials and Results, Patents, Designations, Collaborations, and Other Developments published by Pharma Proff, ALD currently exhibits a proliferating pipeline with 10 therapeutic candidates.



ALD Pipeline Insights

ALD is a X-linked genetic disease which falls under the family of leukodystrophies disorder. The disease is monogenetically inherited from parents to offspring, with 100% penetrance in men and 65% in heterozygous women. It is a multi-system disorder which prominently affects both central and peripheral nervous system, resulting in blindness, seizures and hyperactivity.

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The pathophysiologic condition of disease includes the accumulation of saturated very long chain fatty acids (VLCFA) in serum and tissues of central nervous system, which is a major factor for immune system abnormality and demyelination of neurons. It mainly affects nervous system and adrenal glands and causes various adrenal and neurological problems, such as leg stiffness, muscles spasms and weakness, urinary problems, and sexual dysfunction.

Browse report overview with detailed TOC on "Adrenoleukodystrophy (ALD) Therapeutics Pipeline Analysis 2019, Clinical Trials and Results, Patents, Designations, Collaborations, and Other Developments" at: https://www.pharmaproff.com/report/adrenoleukodystrophy

Insights into Pipeline Segments
According to the research, many drugs acting as a therapeutic against ALD are administered orally. It has been found that oral route of administration is easy to use, non-invasive, and ensures high level of patient satisfaction.

It has been observed that regulatory bodies are granting designations to the drugs in ALD pipeline, in order to pace up the development process. For instance, bluebird bio Inc. ‘s drug candidate, Lenti-D, received Orphan Drug Designation by the USFDA and EMA in 2012; and Breakthrough Therapy Designation by the USFDA in 2018. Similarly, Minoryx Therapeutics S.L. drug, MIN-102, received Orphan Drug Designation by the USFDA in 2017.

Some of the key players involved in the development of ALD are Poxel SA, bluebird bio Inc., Minoryx Therapeutics SL, NeuroVia Inc., SOM Innovation Biotech SL, Viking Therapeutics Inc., Orpheris Inc., MedDay Pharmaceuticals, Applied Genetic Technologies Corporation (AGTC), and Neuralgene.

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